Astragaloside IV, a primary active component of Astragalus membranaceus, has been investigated for its neuroprotective properties in various preclinical studies. Scientific interest in this compound for supporting memory and brain function stems mainly from animal and in vitro research. These studies suggest that Astragaloside IV may exert beneficial effects on cognitive function through several mechanisms, such as reducing oxidative stress, inhibiting neuroinflammation, and modulating neurotransmitter systems. For example, research in rodent models of Alzheimer’s disease demonstrates that Astragaloside IV administration can ameliorate memory impairments, likely due to its antioxidative effects and ability to inhibit neuronal apoptosis. Some studies have also noted the compound’s potential to enhance synaptic plasticity and protect against amyloid-beta-induced neurotoxicity.

However, it is important to note that the supporting evidence is predominantly preclinical. There is a lack of robust clinical trials in humans to confirm these effects or establish appropriate dosing and safety in the context of cognitive or memory support. Traditional use of Astragalus in Chinese medicine is more focused on immune and energy support rather than direct cognitive enhancement. Therefore, while there is a scientific rationale and some early-stage evidence suggesting potential benefit, the overall level of evidence is still limited (rated 2/5), and further high-quality human studies are needed to substantiate its use for memory and brain function.