Evidence supporting the use of: Vitamin B9 (calcium methyltetrahydrofolate)
For the body system: Male Reproductive System

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B9, also known as folate (and in supplement form, calcium methyltetrahydrofolate), has scientific evidence supporting its role in the male reproductive system, although the evidence is moderate rather than strong. Folate is crucial for DNA synthesis, repair, and methylation, which are essential processes in rapidly dividing cells, including sperm cells. Several clinical studies and meta-analyses have examined the relationship between folate status and male fertility parameters. Some studies have reported that adequate folate intake or supplementation is associated with improved sperm count, motility, and lower rates of sperm DNA damage. Additionally, folate deficiency has been linked to increased homocysteine levels, which may negatively impact sperm quality.

However, while observational studies and small clinical trials suggest potential benefits, larger randomized controlled trials have produced mixed results. Some have shown improvements in sperm quality metrics with folate supplementation, often in combination with other micronutrients, but others have found minimal or no effect on fertility outcomes such as pregnancy rates. The use of the specific form, calcium methyltetrahydrofolate, is based on its enhanced bioavailability compared to folic acid.

In summary, there is moderate scientific validation for the use of Vitamin B9 to support male reproductive health, particularly with respect to sperm quality, but the overall evidence does not yet warrant a high rating due to inconsistent findings and limited data on direct fertility outcomes.

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