Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Dehydroepiandrosterone (DHEA) is a steroid hormone produced naturally by the adrenal glands, testicles, and brain. It serves as a precursor to both androgens and estrogens, including testosterone. There is scientific interest in DHEA supplementation for supporting the male reproductive system, particularly in older men or those with low DHEA levels. Some clinical studies have shown that DHEA supplementation may increase serum testosterone levels modestly in older men and may improve some aspects of sexual function, including libido and erectile function, especially in those with adrenal insufficiency. Additionally, DHEA has been investigated in the context of male infertility, with some preliminary studies suggesting potential improvements in sperm parameters, though findings are inconsistent and larger trials are lacking.

However, the overall quality of evidence is moderate at best. Meta-analyses and systematic reviews indicate that while DHEA can raise androgen levels, its direct impact on fertility, sexual performance, or broader aspects of male reproductive health remains uncertain. The benefits observed are often modest, and not all studies report positive effects. Furthermore, long-term safety data are limited, and there are concerns about side effects such as hormonal imbalances and prostate health. As such, while there is scientific rationale and some supporting evidence for DHEA's use in male reproductive health, it is not universally recommended, and professional guidance is advised.

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