Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Sesbania species, including Sesbania sesban and Sesbania grandiflora, have been traditionally used in certain regions of Africa and Asia as herbal remedies for a variety of ailments, including malaria. Ethnobotanical surveys from countries such as Nigeria, India, and Ethiopia document the use of Sesbania leaves, bark, or extracts in traditional medicine to treat symptoms associated with malaria, such as fever and chills. However, the scientific validation for this use is limited. While some in vitro studies have explored the antiplasmodial activity of extracts from various Sesbania species, results are generally preliminary, and there is limited evidence of significant efficacy against Plasmodium species in vivo. Furthermore, no major clinical trials or in-depth pharmacological evaluations support the use of Sesbania as a reliable antimalarial treatment. Its traditional use appears to be based more on local custom and empirical knowledge rather than scientific proof. Therefore, while Sesbania is indeed used in traditional medicine for malaria, the evidence supporting its effectiveness is weak and not sufficient for clinical recommendation.

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