Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Plectranthus amboinicus, commonly known as Indian borage or Cuban oregano, has a long history of use in traditional medicine across Asia and Africa. In several regions, especially in parts of Africa and India, decoctions or infusions of its leaves have been used as a folk remedy for symptoms associated with malaria such as fevers, chills, and headaches. Ethnobotanical surveys report its use among indigenous communities for "malarial fevers," indicating a traditional belief in its efficacy.

However, scientific validation is limited. A handful of in vitro studies have tested extracts of P. amboinicus against Plasmodium falciparum, the parasite responsible for the most severe form of malaria. These studies occasionally show mild to moderate antiplasmodial activity, but the results are inconsistent and not robust enough to support clinical efficacy. There are no published clinical trials or extensive pharmacological evaluations confirming its use for malaria treatment in humans. Thus, the evidence for its use in malaria is rooted in traditional practices, with only preliminary and inconclusive scientific support. Current research does not validate its effectiveness beyond traditional claims, and it should not be considered a replacement for established antimalarial medications.

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