Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Lantana camara is primarily used in the traditional treatment of malaria in various regions, especially in Africa, Asia, and South America. Ethnobotanical surveys have documented its use as an antimalarial remedy, where leaves, roots, or whole plant extracts are prepared as teas or decoctions. The rationale for its use is rooted in indigenous knowledge systems and centuries-old practices. While several in vitro and in vivo studies have investigated the antiplasmodial activity of Lantana camara extracts, most results have shown only moderate efficacy, and none have led to the development of clinically approved antimalarial drugs. The main phytochemicals associated with possible activity are triterpenoids and flavonoids, but their effects are generally less potent than standard antimalarials. There are case reports and some preclinical data suggesting a reduction in parasite load in animal models, but there is insufficient clinical evidence in humans. Toxicity is also a concern, as Lantana camara is known to be poisonous to livestock and potentially to humans at higher doses. In summary, while its traditional use for malaria is well documented, scientific evidence supporting its efficacy and safety remains limited and inconclusive.

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