Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Dichroa febrifuga, commonly known as Chinese quinine, has a long history of traditional use in Chinese medicine for the treatment of malaria. The use of Dichroa, particularly its roots, is documented in ancient Chinese medical texts and it has been employed as an antimalarial remedy for centuries. The main active compound, febrifugine, was isolated in the 20th century and shown to have significant antimalarial activity in laboratory studies. However, clinical use has been limited due to the compound's toxicity and side effects. While there is some preclinical evidence supporting its efficacy, large-scale, well-controlled clinical trials in humans are lacking. Thus, the use of Dichroa for malaria is primarily justified by its traditional use rather than robust scientific validation. Current antimalarial therapies, such as artemisinin derivatives, are preferred due to their proven efficacy and safety profiles. Dichroa's historical significance remains important, as research into febrifugine and related compounds has contributed to the development of modern antimalarial drugs, but its direct use in contemporary medicine is limited and not widely recommended.

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