Synopsis

Source of validity: Traditional
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Colombo, commonly referring to the root of Jateorhiza palmata (also known as calumba), has a history of traditional use in the treatment of malaria, particularly as a bitter tonic rather than a primary antimalarial agent. Historical accounts from the 18th and 19th centuries note its use as a substitute for cinchona bark (the source of quinine), especially when quinine was unavailable or in short supply. The root was valued for its bitter principles, mainly the alkaloid jateorrhizine and related compounds, believed to stimulate appetite and aid recovery from febrile illnesses, including malaria. However, colombo does not contain quinine or other known direct antimalarial compounds. Its use was largely based on its general tonic and digestive properties, and it was primarily utilized to help convalescent patients regain strength after malarial attacks rather than to treat the infection itself. Modern scientific studies do not support direct antimalarial activity of colombo. Thus, while its use for malaria has historical and traditional precedent, there is little to no scientific validation for its efficacy against the malaria parasite itself. In summary, colombo was traditionally used in the context of malaria, mainly for supportive care, and not as a curative treatment. Its role is rooted in tradition rather than evidence-based medicine.

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