Evidence supporting the use of: Clerodendrum indicum
For the health condition: Malaria

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Clerodendrum indicum, commonly known as Turk's Turban or Skyrocket, has a longstanding history of use in traditional medicine systems across Asia, particularly in Ayurveda and folk medicine. Its roots and leaves have been employed for the management of various ailments, including fever-related illnesses such as malaria. Ethnobotanical surveys from regions in India and Southeast Asia document the use of Clerodendrum indicum decoctions or extracts as a remedy to alleviate malarial symptoms, likely due to its antipyretic and anti-inflammatory properties. However, while these traditional practices are well-established, robust scientific validation is limited. Some preliminary in vitro studies have suggested that certain phytochemicals present in Clerodendrum species (like flavonoids, saponins, and terpenoids) may exhibit antiplasmodial activity, but these findings are generally not specific to C. indicum or lack comprehensive in vivo confirmation. No large-scale clinical trials or compelling pharmacological studies currently support its efficacy against malaria in humans. Thus, its use for malaria is primarily grounded in traditional knowledge rather than scientific validation, and the overall quality of evidence is rated as low (2 out of 5). Further research is needed to isolate active compounds, assess their mechanisms, and determine safety and effectiveness in clinical settings.

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