Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Black seed (Nigella sativa) has a long history of use in traditional medicine systems, especially in the Middle East, Africa, and South Asia. Its application for malaria is primarily rooted in traditional practice rather than robust scientific validation. Ethnobotanical surveys from malaria-endemic regions, such as parts of Nigeria and Sudan, report the use of black seed preparations—sometimes as decoctions or mixed with other herbs—as supportive remedies for fever and malaria-like symptoms. These traditional uses are based on the general belief in black seed's ability to strengthen the immune system and its purported antipyretic and anti-inflammatory properties.

Scientific research on Nigella sativa for malaria is limited. A few preclinical studies (mostly in vitro or in animal models) suggest that black seed extracts may have some inhibitory effects on Plasmodium species, the parasites responsible for malaria. However, these findings are preliminary, and there are no robust clinical trials in humans demonstrating efficacy for malaria treatment or prevention. Therefore, while black seed is used in some traditional medicine systems for malaria, current scientific evidence does not substantiate its effectiveness for this condition.

In summary, the use of black seed for malaria is justified by tradition rather than science, and evidence supporting its effectiveness is weak and primarily anecdotal or limited to early-stage laboratory studies.

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