Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Alstonia macrophylla, commonly known as "Devil's Tree" or "Ditabark," has a history of use in traditional medicine systems of South and Southeast Asia for treating a variety of ailments, including malaria. Traditional healers have used decoctions or extracts from the bark and leaves of Alstonia macrophylla as antimalarial remedies. The rationale for its use is primarily based on ethnomedicinal knowledge rather than robust scientific validation.

Scientific studies on Alstonia macrophylla’s efficacy against malaria are limited. Some in vitro studies have identified the presence of alkaloids and other bioactive compounds with potential antiplasmodial activity, but results are preliminary and do not confirm clear clinical effectiveness. As of now, no large-scale clinical trials or comprehensive pharmacological studies exist to definitely support its use in treating malaria. The use of Alstonia macrophylla against malaria is thus best categorized as traditionally justified, with only modest experimental evidence and no clinical validation. The evidence supporting its use for this condition rates as low to moderate (2 out of 5) due to the lack of robust scientific data and reliance on traditional practices.

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