Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Abrus species, particularly Abrus precatorius (commonly known as rosary pea or jequirity), have been used in various traditional medicine systems, including Ayurveda and African folk medicine, for a range of ailments. In some traditional contexts, decoctions or infusions made from the leaves, roots, or seeds have been used to treat symptoms associated with fevers and malaria. However, there is limited direct scientific evidence supporting the efficacy of Abrus species specifically for malaria treatment. Some studies have identified potential antiplasmodial activity in extracts of Abrus precatorius in laboratory settings, but these are preliminary and do not translate into established clinical use. Furthermore, the seeds of Abrus contain abrin, a highly toxic compound, which raises significant safety concerns and limits their use. Most reports of Abrus and malaria are based on ethnobotanical surveys rather than rigorous pharmacological validation. Therefore, while the use of Abrus for malaria is documented in some traditional medicine practices, it is not supported by strong scientific evidence, and its safety profile is problematic. Use of Abrus for malaria should be approached with caution, and safer, validated antimalarial therapies should be prioritized.

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