Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Anthocyanins are naturally occurring flavonoid compounds found in deeply colored fruits and vegetables, such as blueberries, blackcurrants, and purple corn. Their use in supporting or treating Macular Degeneration (specifically age-related macular degeneration, or AMD) is based on their antioxidant and anti-inflammatory properties, which are believed to help protect retinal cells against oxidative stress—a known factor in the development and progression of AMD.

Some scientific studies and preclinical research suggest anthocyanins can reduce oxidative damage in retinal cells, inhibit inflammation, and improve visual function in animal models. Small-scale human studies, such as those involving bilberry extract (high in anthocyanins), report improvements in night vision and retinal blood flow, but these studies are often limited by sample size, study design, or lack of blinding and control. Large, well-designed clinical trials specifically examining anthocyanins for AMD are lacking.

While anthocyanins are commonly included in eye health supplements and are considered safe for consumption, the current level of scientific evidence supporting their use for macular degeneration is weak to moderate (rated 2/5). Most recommendations are based on extrapolation from their antioxidant effects and limited clinical data. They are not a replacement for established AMD interventions such as AREDS2 formula supplementation or medical management. Further research, especially randomized controlled trials in humans, is needed to validate their efficacy for macular degeneration.

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