Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Anthocyanidins are a class of flavonoids found in various fruits and vegetables, especially berries. Their use in supporting or treating age-related macular degeneration (AMD) is primarily based on their antioxidant and anti-inflammatory properties, which are thought to help protect retinal cells from oxidative stress—a key factor in the progression of AMD. Several laboratory and animal studies have demonstrated that anthocyanidins can protect retinal pigment epithelial cells from oxidative damage and may improve visual function in animal models. There are also small clinical studies and observational data suggesting that diets rich in anthocyanidin-containing foods are associated with a lower risk of AMD or slower progression, but these studies are generally limited in size, duration, or quality. No large, high-quality randomized controlled trials have directly established that anthocyanidin supplements prevent or treat AMD in humans. As such, while there is a plausible scientific rationale and some supportive preclinical and early clinical evidence, the overall quality and quantity of evidence is modest. The use of anthocyanidins for AMD is not primarily based on tradition, but rather on emerging scientific interest and limited supportive data. Current clinical guidelines do not recommend anthocyanidins as a standard treatment for AMD, though they may be considered as part of a diet high in fruits and vegetables for general eye health.

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