Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Almond mushroom (Agaricus blazei Murill) has a history of traditional use in Japan, Brazil, and China as a health-promoting food, including support for the immune system and, by extension, conditions like cancer. Specifically for lymphoma, there is some traditional use, particularly in Japanese and Brazilian folk medicine, where the mushroom is believed to enhance vitality and the body’s resistance to disease. However, clinical evidence specifically targeting lymphoma in humans is minimal and not robust. Preclinical studies (in vitro and in animal models) have shown that extracts from Agaricus blazei can stimulate immune function, including activation of NK cells, macrophages, and production of cytokines, which theoretically could contribute to anti-tumor activity. A handful of small human trials and case reports have explored its use as an adjunct in cancer therapy, primarily in solid tumors, but rarely in lymphoma, and with mixed results. No major clinical guidelines endorse almond mushroom as a primary or adjunctive treatment for lymphoma, and the quality of existing studies is generally low, with small sample sizes and lack of blinding or control groups. In summary, use of almond mushroom for lymphoma is grounded more in tradition than in strong scientific evidence, and while immunomodulatory effects are plausible, rigorous clinical validation is lacking.

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