Evidence supporting the use of: Immunoglobulin
For the body system: Lymphatics

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Immunoglobulin (also known as antibodies) is scientifically validated in its use to support the lymphatic (immune) system, particularly in individuals with primary or secondary immunodeficiencies. Immunoglobulin therapy, often administered intravenously (IVIG) or subcutaneously (SCIG), provides passive immunity by supplying functional antibodies that patients are unable to produce in sufficient quantities themselves. This therapy has a well-established role in preventing recurrent infections in conditions such as common variable immunodeficiency (CVID), X-linked agammaglobulinemia, and other disorders where antibody production is impaired. Multiple clinical trials and decades of clinical use have demonstrated that immunoglobulin replacement reduces the frequency and severity of infections, and improves quality of life and survival in these patients.

While immunoglobulin is not typically described as directly supporting "lymphatic drainage," it is an essential component of the adaptive immune system, which is intimately associated with lymphatic organs and tissues (such as lymph nodes, spleen, and lymphatic vessels). The scientific rationale is robust, as immunoglobulins neutralize pathogens and facilitate their removal by the lymphatic and reticuloendothelial systems. However, in healthy individuals without immune deficiency, supplemental immunoglobulin is not indicated for general lymphatic support, and its use is limited to specific, medically diagnosed conditions.

References:
- Orange JS, et al. "Use of intravenous immunoglobulin in human disease: A review of evidence by members of the Primary Immunodeficiency Committee of the AAAAI." J Allergy Clin Immunol. 2006.
- Chapel H, et al. "Immunoglobulin replacement therapy for primary immunodeficiencies: consensus statement." Clin Exp Immunol. 2017.

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