Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Proteolytic enzymes, such as bromelain, papain, and mixtures from animal or plant sources, have a history of traditional use for a variety of inflammatory conditions, including swelling of lymph nodes or glands. These enzymes have been used in traditional medicine systems (particularly in Europe and Asia) with the belief that they help reduce inflammation, edema, and support immune function by enhancing the breakdown of inflammatory mediators and proteins involved in swelling. However, direct scientific studies specifically evaluating proteolytic enzymes for the treatment of swollen lymph nodes or glands are sparse.

Most available research focuses on the ability of proteolytic enzymes to reduce inflammation and edema in post-surgical or traumatic conditions, not specifically lymphadenopathy. Some small clinical studies and case reports suggest potential benefits in reducing general swelling and supporting lymphatic drainage, but robust, high-quality clinical trials are lacking for the specific indication of swollen lymph nodes. The traditional rationale is largely extrapolated from their general anti-inflammatory and anti-edematous properties. In summary, while there is some traditional use and limited indirect scientific support, direct evidence for efficacy in swollen lymph nodes or glands is minimal.

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