Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Calotropis gigantea has been traditionally used in various systems of folk medicine, particularly in Ayurveda and Unani, to address conditions involving swollen lymph nodes or glands. In these traditions, preparations made from the plant—such as poultices of its leaves or latex—are applied topically to reduce inflammation and swelling, including that associated with lymphadenopathy (enlarged lymph nodes). The use is based on the plant’s reputed anti-inflammatory, analgesic, and antimicrobial properties, as described in traditional pharmacopeias and ethnomedicinal records. However, scientific studies specifically validating Calotropis gigantea for the treatment of swollen lymph nodes are sparse. Most modern research focuses on its general anti-inflammatory and antimicrobial properties, with some in vitro and animal studies supporting these effects, but without direct clinical trials for lymphatic conditions. Therefore, while the traditional use is well-documented, robust scientific evidence for efficacy in treating swollen lymph nodes or glands is lacking, warranting a low to moderate evidence rating.

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