Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D is commonly investigated and recommended as a supportive therapy in systemic lupus erythematosus (SLE, or lupus) due to its immunomodulatory properties. Numerous studies have documented that vitamin D deficiency is highly prevalent among people with lupus, likely due to photosensitivity and consequent sun avoidance, which reduces endogenous vitamin D production. Scientific research indicates that low vitamin D levels are associated with increased disease activity and higher risk of flares in SLE patients. Some interventional studies have shown that vitamin D supplementation may reduce disease activity markers, improve fatigue, and possibly modulate immune responses in lupus patients, although results are mixed and the optimal dosing remains uncertain.

Professional rheumatology guidelines, such as those from the American College of Rheumatology, suggest monitoring and correcting vitamin D deficiency in lupus patients, primarily for bone health but also due to potential immunological benefits. However, while these recommendations are based on a body of observational and some interventional studies, there is not yet strong evidence from large, high-quality randomized controlled trials that vitamin D supplementation alone can significantly alter the course of lupus. Therefore, the use of vitamin D in lupus is supported by moderate scientific evidence, mainly for deficiency correction and possibly for adjunctive disease management.

More about Vitamin D (mixed)
More about Lupus

Other ingredients used for Lupus

Other health conditions supported by Vitamin D (mixed)

Products containing Vitamin D (mixed)