Evidence supporting the use of: Vitamin D (ergocalciferol)
For the health condition: Lupus

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D (ergocalciferol, or vitamin D2) supplementation in systemic lupus erythematosus (SLE) is primarily supported by scientific evidence, although the strength of evidence is moderate. Several studies have shown that vitamin D deficiency is prevalent among individuals with lupus, likely due to photosensitivity and sun avoidance, which are common in SLE patients. Observational studies have linked low vitamin D levels to increased disease activity and a higher risk of flares. Some interventional studies suggest that vitamin D supplementation can decrease disease activity markers, such as the SLE Disease Activity Index (SLEDAI), and improve immunological parameters, including reduction in pro-inflammatory cytokines and improvement in regulatory T-cell function. However, these findings are not entirely consistent across all studies. Some randomized controlled trials have shown only modest or no significant clinical benefit. Current rheumatology guidelines recommend monitoring and correcting vitamin D deficiency in SLE patients, primarily to support bone health, but also because of its potential immunomodulatory effects. The evidence does not support vitamin D as a standalone therapy for lupus, but rather as an adjunctive measure, particularly in those with documented deficiency. The consensus is that while vitamin D may help modulate immune function and reduce disease activity in some patients, more large-scale, high-quality trials are needed to define its exact role in SLE management.

More about Vitamin D (ergocalciferol)
More about Lupus

Products containing Vitamin D (ergocalciferol)

We currently have no products on Caring Sunshine that contain this ingredient.