Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Salmon oil is rich in omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). There is some scientific evidence suggesting that omega-3 fatty acids may have beneficial effects for individuals with systemic lupus erythematosus (SLE), primarily due to their anti-inflammatory properties. Several small-scale clinical trials and animal studies have examined omega-3 supplementation in SLE patients. For example, some studies have found modest improvements in disease activity indices, reduction in inflammatory markers, and improvement in endothelial function among patients taking omega-3 supplements, including those derived from salmon oil. A systematic review in 2012 (Kostoglou-Athanassiou et al.), and more recent reviews, conclude that while omega-3 supplementation appears to be safe and may benefit some aspects of lupus—particularly cardiovascular risk and inflammation—the evidence base is limited by small sample sizes, short study durations, and variability in outcome measures. Current clinical guidelines do not recommend omega-3 supplements as a primary therapy for lupus, but they acknowledge potential adjunctive benefits. Overall, salmon oil is used to support lupus based on plausible mechanisms and some positive findings, but the strength of evidence remains moderate to low, justifying a rating of 2 out of 5.

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