Evidence supporting the use of: Quercetin
For the health condition: Lupus

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin, a flavonoid found in various fruits and vegetables, has been investigated for its anti-inflammatory and immunomodulatory properties, which are relevant to autoimmune conditions such as systemic lupus erythematosus (SLE). Preclinical studies, primarily in animal models, suggest that quercetin may reduce inflammation, oxidative stress, and even autoantibody production, all of which are key pathological features of lupus. For example, research published in Scientific Reports (2018) demonstrated that quercetin supplementation in lupus-prone mice attenuated disease activity, lowered serum autoantibody levels, and reduced kidney damage.

At the cellular level, quercetin appears to inhibit the activation of T cells and the production of pro-inflammatory cytokines like TNF-α and IL-6. It also possesses antioxidant properties that may protect tissues from damage caused by lupus-related inflammation. However, human clinical data are very limited. There are no large-scale, high-quality clinical trials that have assessed quercetin’s efficacy or safety in lupus patients. Most available evidence is extrapolated from animal models or in vitro studies, and its relevance to human disease remains uncertain.

Thus, while the scientific rationale for quercetin use in lupus exists and has some preclinical support, the direct evidence in humans is lacking. The current evidence level is rated as 2 out of 5, reflecting promising animal data but insufficient clinical validation. Consultation with healthcare providers is recommended before using quercetin as part of lupus management.

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