Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Cortisol, or more commonly its synthetic analogs (such as prednisone, hydrocortisone, and methylprednisolone), are widely used in the treatment of systemic lupus erythematosus (SLE, or lupus). The use of corticosteroids in lupus is strongly supported by scientific evidence and is a cornerstone of lupus management, particularly for moderate to severe disease or during disease flares. Corticosteroids exert their therapeutic effect primarily through their potent anti-inflammatory and immunosuppressive actions. They suppress the overactive immune response that underlies lupus, thereby reducing inflammation and organ damage.

Multiple clinical guidelines, including those from the American College of Rheumatology and the European League Against Rheumatism, recommend corticosteroids for the management of lupus, especially when there is organ involvement (such as nephritis, cerebritis, or hematologic manifestations). Numerous randomized controlled trials and decades of clinical experience have demonstrated their efficacy in rapidly controlling inflammation and preventing irreversible organ damage.

However, long-term use of corticosteroids is associated with significant side effects, and thus, their use is carefully balanced against potential risks. The scientific validation for their use is robust, but ongoing efforts are made to minimize exposure through steroid-sparing strategies when possible.

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