Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Androstenetriol (5-Androstenetriol or 5-AET) is a naturally occurring steroid hormone in the human body, related to dehydroepiandrosterone (DHEA). There is some scientific evidence suggesting its potential role in modulating immune responses, which has led to limited investigation for autoimmune diseases such as systemic lupus erythematosus (SLE, or lupus). The main scientific rationale comes from early studies showing that androstenetriol can stimulate immune function and counteract some of the immunosuppressive effects induced by corticosteroids or other stressors. Animal studies have indicated that 5-AET may enhance resistance to infections and modulate cytokine profiles. In the context of lupus, a few preclinical studies and small pilot clinical trials have explored the use of DHEA (a related steroid) and its metabolites, including androstenetriol, for their potential to improve symptoms and reduce reliance on corticosteroids. However, most of the clinical research has centered on DHEA itself, with androstenetriol being less well studied. The evidence for androstenetriol specifically in lupus treatment is very limited, with no large-scale, well-controlled clinical trials demonstrating clear benefit or establishing safety. Thus, while there is a scientific basis for interest in androstenetriol as an immune modulator, the current evidence supporting its use in lupus is weak and preliminary.

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