Evidence supporting the use of: Vitamin B6 (pyridoxal 5-phosphate)
For the health condition: Liver Detoxification

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6, particularly in its active form pyridoxal 5'-phosphate (PLP), has some scientific basis for supporting liver detoxification, but the evidence is limited and not robust. B6 is a critical coenzyme in numerous metabolic processes, including amino acid metabolism, neurotransmitter synthesis, and the functioning of the transsulfuration pathway. The transsulfuration pathway is significant in liver detoxification because it helps convert homocysteine to cysteine, which is then used for glutathione synthesis. Glutathione is a major antioxidant and detoxifying molecule in the liver, playing a central role in phase II detoxification processes. Some studies have shown that B6 deficiency can impair glutathione production and compromise antioxidant defenses in the liver. Animal studies and a few human observational studies indicate that adequate B6 status is associated with better liver function and reduced markers of oxidative stress. However, there is a lack of direct clinical trials demonstrating that B6 supplementation alone significantly enhances liver detoxification in humans, especially in the absence of deficiency. Most evidence comes from mechanistic studies or broader research on B vitamins in liver health and not from targeted intervention trials. In summary, while there is a biological rationale and some scientific support for the role of B6 in liver detoxification pathways, especially due to its involvement in glutathione synthesis, high-quality clinical evidence specifically validating B6 supplementation for liver detoxification is limited.

More about Vitamin B6 (pyridoxal 5-phosphate)
More about Liver Detoxification

Other ingredients used for Liver Detoxification

Alfalfa
Aloe vera
alpha-ketoglutarate (AKG)
amino acids
green chiretta
anthocyanins
apple
apricot
arjun tree
artichoke
asparagus
astragalus
barberry
barley
beet
Myrobalan
berberine
beta caryophyllene
betel
black cumin
black garlic
radish
Indian frankincense
bovine liver
branched-chain amino acids
bupleurum falcatum
burdock
catalase
caterpillar mushroom
chaga mushroom
chicory
Chinese salvia root
chlorella
chokeberry
cinnamon
Coptis chinensis
cordyceps
cucumber
turmeric
curcumin
cuspidatum root
d-glucarate
dandelion
diallyl disulfide (DADS)
epigallocatechin gallate (EGCG)
gardenia
gentian root
ginger
gooseberry
green tea
hibiscus
Indian gum arabic tree
indole-3-carbinol
honeysuckle
knotweed
jujube
kale
kudzu
L-cysteine
L-glutathione
L-methionine
L-ornithine
Lentinula edodes mycelia
licorice root
liquid liver fractions
lophatherum leaf
lovage
Milk thistle
Moringa
Naringin
Nettle
Niacinamide (vitamin B3)
oleanolic acid
orange
perilla
phosphatidylcholine
phospholipids
pollen
pumpkin
quercetin
redcurrant
reishi mushroom
rhubarb root
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
selenium
silymarin
spirulina
vegetable and fruit blend (proprietary)
vitamin B6
vitamin C
vitamin E
seaweed
Wasabi
Watercress
Watermelon
wheat grass
Whey protein
Mulberry
Zinc
sarsaparilla
cascara sagrada
typhonium
Neem tree
Enicostemma littorale
Clerodendrum indicum
smilax
Tinospora cordifolia
Fumaria parviflora
picrorhiza kurroa
Rubia cordifolia
Swertia
lingzhi
Szechuan lovage
goldenrod
bile salt
Morus
Myrrh
root tuber
chrysanthemum
ganoderma
lotus seed
birch
couch grass
sheep's sorrel
anemarrhena asphodeloides
purslane
coix
Polyporus
Gentiana macrophylla
cleavers
noni
biota seed
goji berry
Algae
ashitaba
soursop
arjuna
Akebia
ankaflavin
anthraquinone
Ardisia
Agrimony
apigenin
Antrodia camphorata
Achyranthes
anamu
Albizia
AHCC
aucubin
andrographolide
avocado
Albumin
American Liverleaf
Appleblossom Cassia
Asam gelugor
alpha-lipoic acid
astragaloside
Andrographis
Adzuki bean
Alstonia scholaris
Agrimonia pilosa
Allyl sulfide
Alisma
Allium tuberosum
Amor seco
Arjunolic acid
astragalin
atractylone
black seed
Baikal Skullcap
blue flag
borotutu
blackthorn
bergenin
Blepharis
balsam
Brassica
belleric myrobalan
Beef liver
Barleria
Berberis (unspecified)
baicalein
bael
butternut
Basidiomycota
boldo
black gram
Baccharoides anthelmintica
banyan
back nightshade
bitter principals
bacteria
black root
Bifidobacteria
BCAA
Bupleurum
benzyl isothiocyanate
Bassia scoparia
Bergenia
bignay
bottle gourd
centaury
Chinese silkvine
cholic acid
carqueja
chebulic acid
coriolus mushroom
coriander
Clerodendrum phlomidis
Centaurium erythraea
Cyathula
Chinese fleeceflower
cynarin
Chinese pond turtle
cruciferous
Centella asiatica
capers
chanca piedra
celandine
cinnamic acid
Chinese Ligustrum berry
copalchi
corktree
C-phycocyanin
cabbage
chirata
calamus
chebulinic acid
corilagin
coumaric acid
cynaropicrin
Cynodon dactylon
Carthamus
Clerodendrum indicum
diallyl sulfide
dihydromyricetin
DL-Methionine
deoxyandrographolides
dithiolthiones
Desmodium
duckweed
ellagic acid
Erodium cicutarium
emblicanin
endive
Embelia
ellagitannin
emodin
fucoidan
Flueggea suffruticosa
fumitory
fo-ti
Ficus religiosa
flavanones
Ficus simplicissima
flavans
flavonones
flavonolignan
gallic acid
genipap
Gypenoside
gamma-glutamylcysteine
gallate
Glycophospholipid
Glycosaponin
Glutathione
Glycine
garden cress
Gardenia jasminoides
Glucoraphanin
Glycyrrhizin
golden shower tree
Glucuronic acid
Glucaric acid
horse gram
Hygrophila
Hemidesmus
Homalomena
Indian nightshade
isosilybin
iridoids
Indian sarsparilla
isothiocyanates
Java tea
Jurubeba
Job\'s tears
Jatoba
Kokam
Kutkins
Kombucha
knotgrass
kuding tea
Lycium
loquat
Lophira lanceolata
limonene
Ligustrum
Lindera
Leptadenia
little ironweed
liverwort
Loranthus
Mesua
Mung bean
Myrosinase
Mondo grass
Maclura tricuspidata
Millettia
Nardostachys
Ornithine
Oldenlandia diffusa
Operculina turpethum
Oxymatrine
Osmanthus
ornithine L-aspartic acid
Osthole
Premna
Picroside
polysaccharides
Pleurotus eryngii
pointed gourd
pu-er tea
Prickly Pear Cactus
Polygonatum
paeoniflorin
Polygonum
Plectranthus amboinicus
Qin Jiao
rosthorn snake gourd
Ribose-l-cysteine
rosmarinic acid
radicchio
Rubiaceae
Rooibos
Rubia yunnanensis
Rumex acetosa
Rhamnus nakaharai
rhubarb
Scoparia dulcis
Selenocysteine
Selenomethionine
S-Methylmethionine
Silybin
Sarivan
Syringic acid
Solanum anguivi
Salvianolic acid
Sweet Woodruff
Schisandrins
Scabrous Gentian
Silydianin
Silychristin
Semecarpus anacardium
Scirpus
Stachytarpheta cayennensis
Schizandrol A
Scopoletin
Silybum
Sulfur
Stone Root
Sargassum
Sulforaphane
Terminalia
Tumerone
Taraxacin
Thistle
Taurochenodeoxycholic acid
Taurocholic acid
Tanshinone
Taurodeoxycholic acid
Taraxasterol
Trametes
Taraxacum
Taraxol
Theabrownin
Ursolic Acid
Vine tea
Withanolides
Wax Gourd
Walnut
Xanthorrhizol
Yuzu
Yellow-Fruit Nightshade
Yellow Dock
Yin Chen
Zingerone

Products containing Vitamin B6 (pyridoxal 5-phosphate)

We currently have no products on Caring Sunshine that contain this ingredient.