Evidence supporting the use of: SOD (Superoxide Dismutase, antioxidant activity)
For the health condition: Liver Detoxification

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Superoxide Dismutase (SOD) is an endogenous antioxidant enzyme crucial for neutralizing superoxide radicals, thereby protecting cells from oxidative stress. The liver, as a central organ in detoxification, is particularly susceptible to oxidative damage due to its role in metabolizing toxins and drugs. Several preclinical studies, primarily in animal models and in vitro, indicate that SOD activity in the liver is associated with protection against chemically-induced hepatic injury and oxidative stress. Supplementation with SOD or SOD-mimetic compounds has been shown to reduce markers of liver damage and oxidative stress in these models.

However, direct clinical evidence in humans supporting the use of exogenous SOD for liver detoxification or as a therapeutic agent in liver disease is limited and inconclusive. Challenges include SOD's poor oral bioavailability and rapid degradation in the digestive tract, though some formulations attempt to address this. Most human studies on antioxidants and liver health focus on other agents (e.g., vitamin E, silymarin), with SOD itself remaining under-researched.

In summary, while there is a plausible biochemical rationale and supportive preclinical evidence for SOD in liver protection and antioxidant defense, robust clinical evidence in humans is lacking. Therefore, the scientific justification exists primarily at the mechanistic and preclinical level, supporting a modest evidence rating.

More about SOD (Superoxide Dismutase, antioxidant activity)
More about Liver Detoxification

Other ingredients used for Liver Detoxification

alfalfa
aloe vera
alpha-ketoglutarate (AKG)
amino acids
green chiretta
anthocyanins
apple
apricot
arjun tree
artichoke
asparagus
astragalus
barberry
barley
beet
myrobalan
berberine
beta caryophyllene
betel
black cumin
black garlic
radish
Indian frankincense
bovine liver
branched-chain amino acids
bupleurum falcatum
burdock
catalase
caterpillar mushroom
chaga mushroom
chicory
Chinese salvia root
chlorella
chokeberry
cinnamon
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cordyceps
cucumber
turmeric
curcumin
cuspidatum root
d-glucarate
dandelion
diallyl disulfide (DADS)
epigallocatechin gallate (EGCG)
gardenia
gentian root
ginger
gooseberry
green tea
hibiscus
Indian gum arabic tree
indole-3-carbinol
honeysuckle
knotweed
jujube
kale
kudzu
l-cysteine
l-glutathione
l-methionine
l-ornithine
lentinula edodes mycelia
licorice root
liquid liver fractions
lophatherum leaf
lovage
milk thistle
moringa
naringin
nettle
niacinamide (vitamin B3)
oleanolic acid
orange
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phosphatidylcholine
phospholipids
pollen
pumpkin
quercetin
redcurrant
reishi mushroom
rhubarb root
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
selenium
silymarin
spirulina
vegetable and fruit blend (proprietary)
vitamin B6
vitamin C
vitamin E
seaweed
wasabia japonica
watercress
watermelon
wheat grass
whey protein
mulberry
zinc
sarsaparilla
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fumaria parviflora
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lingusticum wallichii
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ganoderma
lotus seed
birch
couch grass
sheep's sorrel
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purslane
coix
polyporus
gentiana macrophylla
cleavers
noni
biota seed
goji berry
algae
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soursop
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Agrimony
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Arjunolic acid
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Atractylone
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Borotutu
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bergenin
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Brassica
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Beef liver
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Bael
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Basidiomycota
boldo
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Baccharoides anthelmintica
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Black Nightshade
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BCAA
Bupleurum
benzyl isothiocyanate
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cholic acid
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Celandine
Cinnamic Acid
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Cabbage
Chirata
Calamus
Chebulinic acid
Corilagin
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Diallyl sulfide
Dihydromyricetin
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Desmodium
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Ellagic Acid
Erodium cicutarium
Emblicanin
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Embelia
Ellagitannin
Emodin
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Fo-Ti
Ficus religiosa
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Ficus simplicissima
Flavans
Flavonones
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Gallic Acid
Genipap
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Gallate
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Glycine
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Products containing SOD (Superoxide Dismutase, antioxidant activity)

We currently have no products on Caring Sunshine that contain this ingredient.