Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-proline is an amino acid that plays a key role in the synthesis of collagen, which is a major structural protein in ligaments, tendons, skin, and other connective tissues. Scientific interest in L-proline for ligament support arises from its biochemical function as a building block of collagen fibers. Collagen types I and III, which are abundant in ligaments, require proline and its derivative hydroxyproline for proper triple-helix formation and stability. Some in vitro and animal studies demonstrate that supplementing with proline can increase collagen synthesis in fibroblasts and may enhance tissue repair. However, direct clinical evidence in humans for proline supplementation accelerating ligament healing or improving outcomes after injury is limited or lacking. Most evidence comes from basic science research or extrapolation from the nutritional requirements for collagen production rather than randomized controlled trials in patients with ligament injuries. Thus, while the rationale for its use is scientifically plausible, the evidence is considered weak to moderate, and it is not a standard part of medical management for ligament injuries. More robust clinical research is needed to determine the efficacy and optimal dosing of L-proline in supporting ligament healing in humans.

More about l-proline
More about Ligaments (torn or injured)

Other ingredients used for Ligaments (torn or injured)

Other health conditions supported by l-proline

Products containing l-proline

Nature's Sunshine Free Amino Acids
Nature's Sunshine Target TS-II Formula
Nature's Sunshine VitaWave