Vitamin E has been traditionally used and scientifically investigated for its role in supporting the healing of various types of lesions, especially in the skin and mucous membranes. As an antioxidant, vitamin E (primarily as alpha-tocopherol) neutralizes free radicals, which are known to impair wound healing and contribute to tissue damage. This antioxidative property forms the primary scientific rationale for its use in treating lesions.

Clinical studies have produced mixed results regarding vitamin E’s efficacy in lesion healing. Some small clinical trials and case reports suggest that topical application of vitamin E may reduce scarring and improve the appearance of healed wounds, such as surgical incisions and burns. It is also sometimes used for oral lesions, like recurrent aphthous stomatitis, with some reports of symptomatic improvement. However, other studies have found no significant benefit, and some have reported allergic reactions and contact dermatitis with topical use.

Systematic reviews generally conclude that while there is a plausible biological mechanism for vitamin E in lesion healing, the overall quality of evidence is low and inconsistent. Therefore, the use of vitamin E for supporting or treating lesions is partially justified by scientific rationale but lacks robust, consistent clinical evidence. Its use remains popular, but it should be approached cautiously due to the potential for adverse skin reactions in some individuals.