Evidence supporting the use of: Vitamin D
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D has some scientific basis for its use in supporting intestinal barrier function, which is often referred to in the context of "Leaky Gut Syndrome" (increased intestinal permeability). Several experimental and clinical studies have explored the role of vitamin D in gut health. Vitamin D receptors (VDRs) are expressed in intestinal epithelial cells, and activation of these receptors has been shown to help maintain the integrity of tight junctions—protein complexes that regulate the permeability of the intestinal barrier.

Animal studies suggest that vitamin D deficiency can disrupt gut barrier function, leading to increased permeability. Some in vitro and animal research indicates that vitamin D supplementation may restore or preserve the function of tight junction proteins such as occludin and claudins, reducing the risk of unwanted particles and bacteria crossing the gut wall. In humans, observational studies have found associations between low vitamin D status and increased gut permeability, as well as higher rates of gastrointestinal inflammatory diseases (e.g., inflammatory bowel disease).

However, there is limited direct clinical evidence specifically supporting the use of vitamin D supplementation to treat "Leaky Gut Syndrome" as a standalone condition in humans. Most studies focus on related disorders or use surrogate biomarkers. As a result, while mechanistic and preliminary human data are promising, robust randomized controlled trials in this specific context are lacking, warranting a moderate but not high evidence rating.

More about vitamin D
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Other health conditions supported by vitamin D

Acne
Allergies (food)
Allergies (respiratory)
Alzheimer's Disease
Amenorrhea
Anemia
Anorexia
Apathy
Arrhythmia
Arteriosclerosis
Arthritis
Asthma
Autism
Autoimmune Disorders
Backache
Birth Defects (prevention)
Body Building
Broken Bones
Calcium Deficiency
Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Cardiovascular Disease
Celiac Disease
Chronic Obstructive Pulmonary Disorder
Colds (antiviral)
Colds (general)
Colds (prevention)
Colds (with fever)
Concentration (poor)
Concussions
Confusion
Congestive Heart Failure
Contagious Diseases
Convalescence
Convulsions
Cramps (menstrual)
Cramps and Spasms
Crohn's Disease
Cystic Breast Disease
Cystic Fibrosis
Dandruff
Debility
Dementia
Depression
Dermatitis
Diabetes
Diabetic Retinopathy
Erectile Dysfunction
Estrogen (low)
Fatigue
Fibroids (uterine)
Fibromyalgia Syndrome
Fibrosis
Grave's Disease
Grief and Sadness
Hair (loss or thinning)
Hair Care (general)
Hashimoto's Disease
Headache (cluster)
Heart (weakness)
Hypertension
Hypothyroid
Infection
Infection (bacterial)
Infection (viral)
Infertility
Inflammation
Inflammatory Bowel Disorders
Influenza
Injuries
Irritable Bowel Syndrome
Itching
Knees (weak)
Leaky Gut Syndrome
Leprosy
Lesions
Leukemia
Lou Gehrig's Disease
Lupus
Lymphoma
Melanoma
Memory and Brain Function
Menopause
Menstrual Irregularity
Mental Illness
Metabolic Syndrome
Migraine
Miscarriage (prevention)
Mood Swings
Multiple Sclerosis
Muscle Tone (lack of)
Muscular Dystrophy
Myasthenia Gravis
Nephritis
Nerve Damage
Nervous Exhaustion
Numbness
Nursing
Obsessive Compulsive Disorder
Oral Surgery
Osteoporosis
Pain (general remedies for)
Pancreatitis
Paralysis
Parkinson's Disease
Peripheral Neuropathy
PMS (general)
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Pneumonia
Polyps
Post Partum Depression
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Prostatitis
Psoriasis
Rheumatoid Arthritis
Schizophrenia
Sciatica
Seasonal Affective Disorder
Senility
Tuberculosis