Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Oligosaccharides, particularly prebiotic types like fructooligosaccharides (FOS) and galactooligosaccharides (GOS), have been investigated for their potential to support gut health, including conditions such as Leaky Gut Syndrome (increased intestinal permeability). The rationale for their use is that oligosaccharides serve as food for beneficial gut bacteria, such as Bifidobacteria and Lactobacilli, which can help maintain a healthy gut barrier and modulate inflammation. Several animal and in vitro studies suggest that prebiotics can enhance the production of short-chain fatty acids (SCFAs), such as butyrate, which support the integrity of tight junctions in the intestinal epithelium. However, direct clinical evidence in humans specifically linking oligosaccharide supplementation to improved outcomes in Leaky Gut Syndrome is limited. Most human studies focus on general markers of gut health, not on diagnosed leaky gut or intestinal permeability as a primary endpoint. While there is a plausible mechanism and supportive preclinical data, the evidence in humans is preliminary and insufficient to strongly recommend oligosaccharides specifically for Leaky Gut Syndrome at this time. More high-quality, targeted clinical trials are needed to confirm their efficacy for this condition.

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