Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus species are commonly used in probiotic supplements and have been investigated for their effects on gut barrier function, which is central to the concept of "Leaky Gut Syndrome" (increased intestinal permeability). Scientific evidence supporting their use is moderate but not definitive. Several animal studies and small human trials suggest that certain Lactobacillus strains (such as L. rhamnosus GG and L. plantarum) can enhance tight junction protein expression, reduce inflammation, and decrease gut permeability under specific conditions. These effects have been observed in models of inflammatory bowel disease, irritable bowel syndrome, and after antibiotic or NSAID use. However, "Leaky Gut Syndrome" as a distinct clinical diagnosis remains controversial and is not widely accepted in mainstream medicine. Most clinical studies address increased intestinal permeability in the context of other, recognized diseases rather than as an isolated syndrome.

Meta-analyses and systematic reviews generally conclude that probiotics including Lactobacillus may improve symptoms and markers of gut permeability in some gastrointestinal conditions, but more robust, large-scale human trials are needed. The evidence is not strong enough to recommend unspecified Lactobacillus strains as a primary or universal treatment for "Leaky Gut Syndrome," and results may be strain-specific. Overall, the scientific support exists but is limited and not conclusive.

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