Evidence supporting the use of: Lactobacillus rhamnosus
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus rhamnosus is a probiotic bacterium that has been investigated for its potential to support gut health, including conditions such as "Leaky Gut Syndrome," also known as increased intestinal permeability. While "Leaky Gut Syndrome" is not universally recognized as a formal medical diagnosis, increased intestinal permeability is a documented phenomenon in both clinical and experimental research. Several in vitro and animal studies suggest that L. rhamnosus can enhance mucosal barrier function, modulate immune responses, and reduce inflammation in the gut. For example, L. rhamnosus GG has been shown to upregulate the expression of tight junction proteins such as occludin and zonula occludens-1, which are critical for maintaining the integrity of the intestinal barrier. In human studies, the evidence is more limited and primarily indirect. Some clinical trials have reported improvements in symptoms of IBS (Irritable Bowel Syndrome) and other gastrointestinal disorders with L. rhamnosus supplementation, but very few have directly measured changes in intestinal permeability. Most human data are extrapolated from studies on related gut disorders or from biomarker changes rather than direct clinical outcomes. Therefore, while there is a scientific rationale and some preclinical and early clinical evidence supporting its use for intestinal barrier support, robust clinical trials directly addressing "Leaky Gut Syndrome" in humans are lacking. As a result, the evidence rating given here is moderate to low (2 out of 5).

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