Evidence supporting the use of: Lactobacillus bulgaricus
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus bulgaricus is a probiotic bacterium traditionally used in yogurt production. Its use for Leaky Gut Syndrome (also known as increased intestinal permeability) is based on the emerging understanding of the gut microbiome’s role in gut barrier integrity. Some scientific studies have demonstrated that L. bulgaricus and other probiotic strains can help enhance the mucosal barrier, modulate immune responses, and support the tight junctions between intestinal epithelial cells. For example, research has shown that probiotic supplementation can reduce gut permeability in animal models and some small human trials (e.g., in patients with irritable bowel syndrome or after NSAID use). However, most of these studies use multi-strain formulations rather than L. bulgaricus alone, and direct evidence specifically linking L. bulgaricus to improvements in leaky gut is limited.

While the theoretical rationale is strong—probiotics can suppress pathogenic bacteria, reduce inflammation, and enhance mucus production—the clinical evidence remains modest. No large-scale, high-quality randomized controlled trials have conclusively demonstrated that L. bulgaricus alone can treat or significantly improve Leaky Gut Syndrome. Therefore, while its use is grounded in contemporary scientific theory and some early-stage research, the current evidence base is limited and further research is needed to make firm recommendations.

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