Evidence supporting the use of: L-glutamine
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glutamine is an amino acid that has gained popularity as a supplement for supporting intestinal health, particularly in the context of "Leaky Gut Syndrome" (increased intestinal permeability). There is some scientific rationale and preliminary research supporting its use, though the evidence is not robust or definitive, especially in the context of human clinical trials for Leaky Gut Syndrome specifically.

Animal and in vitro studies have shown that glutamine is a major fuel source for enterocytes (the cells lining the intestines) and helps maintain the integrity of the gut barrier by supporting tight junction proteins. Some small human studies have found that glutamine supplementation may reduce intestinal permeability in critically ill patients or those undergoing certain medical treatments (e.g., chemotherapy), but these patient populations are not fully representative of the general population seeking to address "leaky gut."

There is a lack of large, well-controlled clinical trials directly demonstrating that L-glutamine supplementation can treat or reverse Leaky Gut Syndrome in otherwise healthy individuals or those with vague gastrointestinal complaints. As such, while there is scientific plausibility and some encouraging preliminary data, the strength of evidence remains limited (rated 2/5). More research is needed to establish clear clinical guidelines for L-glutamine use in this context.

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