Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Immunoglobulin G (IgG), often derived from bovine serum (as in "serum-derived bovine immunoglobulins" or SBI), has been investigated as a supplement to support gut health, including conditions broadly described as "Leaky Gut Syndrome" (increased intestinal permeability). While Leaky Gut Syndrome is not universally recognized as a formal medical diagnosis, increased intestinal permeability is documented in certain gastrointestinal diseases like irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and celiac disease.

Scientific studies, mostly small-scale clinical trials and animal models, suggest that oral immunoglobulins may bind to microbial components and toxins, reducing gut inflammation and supporting mucosal barrier function. A few randomized controlled trials have reported that SBI supplementation can improve gastrointestinal symptoms, decrease intestinal inflammation, and potentially reduce permeability in patients with IBS-D (diarrhea-predominant IBS) and HIV-associated enteropathy. However, these studies are limited in size and scope, and there are few high-quality trials specifically addressing "Leaky Gut Syndrome" as popularly defined.

Overall, while there is some scientific rationale and preliminary data supporting the use of orally administered immunoglobulin G for gut barrier support, the evidence is moderate at best, and not universally accepted. More large, rigorous clinical trials are needed to confirm efficacy, especially in the context of non-disease-specific "leaky gut." Nonetheless, the use of IgG in this context is justified by emerging scientific evidence rather than tradition.

More about immunoglobin G
More about Leaky Gut Syndrome

Other ingredients used for Leaky Gut Syndrome

Other health conditions supported by immunoglobin G

Products containing immunoglobin G