Evidence supporting the use of: Bifidobacterium longum
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium longum is considered to have some scientific support for use in Leaky Gut Syndrome (also known as increased intestinal permeability), but the evidence is limited and emerging. B. longum is a naturally occurring probiotic bacterium found in the human gastrointestinal tract and is widely studied for its effects on gut health. Several preclinical studies (in animal models) and a few small human trials suggest that B. longum supplementation can help reinforce the intestinal barrier, reduce inflammation, and positively modulate the gut microbiota.

Specifically, research has shown that B. longum may enhance the expression of tight junction proteins (such as occludin and zonula occludens-1), which are crucial for maintaining the integrity of the gut lining. By strengthening these proteins, B. longum may help prevent unwanted substances from crossing the gut barrier and entering the bloodstream. Additionally, B. longum can produce short-chain fatty acids and other metabolites that support gut health and immune function.

However, most clinical trials that exist focus on related conditions such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), or general gastrointestinal health, rather than specifically diagnosing and treating "Leaky Gut Syndrome" as a standalone clinical entity. While the mechanistic rationale is strong and animal studies are promising, there is a lack of large, well-controlled human trials directly demonstrating efficacy for Leaky Gut Syndrome. Thus, while the use of B. longum is scientifically plausible and supported by some preliminary evidence, it currently rates as a 2/5 for evidence strength.

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