Evidence supporting the use of: Bifidobacterium infantis
For the health condition: Leaky Gut Syndrome

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium infantis is a probiotic bacterium that has been studied for its potential benefits in gut health, particularly in relation to inflammatory bowel diseases and other gastrointestinal conditions. Its use in supporting or treating "Leaky Gut Syndrome" (also known as increased intestinal permeability) is primarily based on scientific exploration rather than traditional usage. Several studies have demonstrated that B. infantis can modulate the gut microbiome, enhance mucosal barrier function, and reduce inflammation in the gut. For example, in both animal models and some human clinical trials, supplementation with B. infantis has been shown to upregulate tight junction proteins, which are crucial for maintaining the integrity of the intestinal barrier. Additionally, B. infantis can produce short-chain fatty acids, such as acetate, that nourish colonocytes and further support barrier function.

However, while there is a plausible mechanism and some supportive data, the overall body of evidence specific to "Leaky Gut Syndrome" in humans is limited. Most research focuses on broader gastrointestinal disorders, and few high-quality, large-scale, randomized controlled trials have directly evaluated B. infantis for leaky gut as a primary outcome. Thus, although there is scientific rationale and some promising results, the evidence level is moderate to low (rated 2/5) for this specific indication. Further clinical studies are needed to establish its efficacy and optimal use for leaky gut in humans.

More about Bifidobacterium infantis
More about Leaky Gut Syndrome