Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium adolescentis is a probiotic bacterium that has been studied for its potential role in supporting gut barrier function and modulating intestinal inflammation, two aspects relevant to "Leaky Gut Syndrome" (increased intestinal permeability). Preclinical studies, particularly in animal models, have shown that B. adolescentis can enhance the expression of tight junction proteins (such as occludin and ZO-1) and may reduce endotoxin (LPS)-induced inflammation in the gut. For example, some mouse studies have found that supplementation with B. adolescentis helps to restore gut barrier integrity and modulate immune responses, potentially reducing gut permeability.

In humans, direct clinical studies investigating the use of B. adolescentis for "Leaky Gut Syndrome" are limited. However, some small trials and observational studies indicate that B. adolescentis is often reduced in individuals with conditions associated with increased gut permeability (such as IBS or IBD). Its administration as part of multi-strain probiotic formulations has shown modest improvements in gut barrier markers or symptoms in certain populations.

Overall, while there is promising preclinical evidence and some indirect human data, robust clinical trials specifically validating B. adolescentis for "Leaky Gut Syndrome" are lacking. Therefore, the current scientific evidence supporting its use for this specific condition is limited, warranting a moderate-low evidence score.

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