Sesame seed (Sesamum indicum) has a longstanding history in traditional medicine systems, particularly in Traditional Chinese Medicine (TCM) and Ayurveda. In TCM, black sesame seeds are used to "moisten the intestines" and treat constipation, especially in older adults or individuals with dry stools. The seeds are believed to nourish and tonify the yin, which includes moistening dryness within the large intestine (colon). Similarly, Ayurveda considers sesame seeds as a remedy for promoting bowel regularity and relieving constipation, attributing these effects to their oily nature and high fiber content.

Scientifically, sesame seeds are a good source of dietary fiber and healthy fats, both of which can support digestive health and regular bowel movements. However, there is a lack of high-quality clinical studies directly investigating the effect of sesame seeds on colon health or specific large intestine conditions in humans. Most evidence supporting their use in this context is based on traditional knowledge and anecdotal reports rather than robust scientific validation. As such, while there is some biological plausibility and traditional precedent for their use to support the large intestine, the evidence is not strong or rigorously validated.