Senna occidentalis, also known as coffee senna, has a long history of traditional use as a remedy for constipation and to support the health and function of the large intestines (colon). The primary reason for its use lies in the presence of anthraquinone glycosides, such as sennosides, which have well-known stimulant laxative effects. These compounds act by irritating the lining of the colon, promoting peristalsis, and increasing water secretion into the bowels, thus facilitating bowel movements. Historical records from Ayurveda, traditional African medicine, and other ethnobotanical sources document the use of Senna species, including S. occidentalis, as purgatives and for treating constipation.

While Senna alexandrina (senna leaf and pod) is more widely studied and recognized in both traditional and scientific literature for these uses, Senna occidentalis is employed similarly in regions where it is more readily available. However, scientific validation specifically for S. occidentalis is limited compared to other Senna species; most available data are extrapolated from the general pharmacology of sennosides. Adverse effects, especially with prolonged use, are also noted in traditional sources, including potential for dependency and electrolyte imbalance. In summary, the use of S. occidentalis to support colon function is justified by strong traditional precedent and phytochemical similarity to validated Senna species, but direct scientific evidence is relatively sparse.