Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Lactobacillus rhamnosus (often referred to as Lactococcus rhamnosus, though the accepted genus is Lactobacillus) is a well-studied probiotic bacterium with documented benefits for large intestine (colon) health. Multiple clinical trials and meta-analyses have demonstrated its efficacy in supporting gut health, particularly in the prevention and treatment of antibiotic-associated diarrhea and some forms of infectious diarrhea. For example, L. rhamnosus GG is one of the best-characterized probiotic strains and has shown to help restore the balance of intestinal microflora disrupted by antibiotics and to reduce the duration and severity of diarrhea in both children and adults. Furthermore, studies suggest that L. rhamnosus may help maintain remission in certain cases of inflammatory bowel disease and may alleviate symptoms of irritable bowel syndrome (IBS), although the evidence here is less robust than for infectious diarrhea. The proposed mechanisms include competitive inhibition of pathogenic bacteria, enhancement of the gut barrier function, modulation of the host immune response, and production of bioactive compounds such as short-chain fatty acids (SCFAs) that benefit colon health. Collectively, these findings provide a strong scientific rationale for the use of L. rhamnosus in supporting the health of the large intestine, justifying its inclusion in many probiotic formulations targeting gut and colon health.

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