Evidence supporting the use of: Goldenseal
For the body system: Large Intestines (Colon)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Goldenseal (Hydrastis canadensis) has a long history of use in traditional herbal medicine, particularly in North America. Indigenous peoples and later herbalists employed goldenseal primarily for its purported antimicrobial and anti-inflammatory properties, often using it to address digestive complaints, including those related to the large intestines such as diarrhea, dysentery, and general gastrointestinal disturbances. The root contains alkaloids like berberine, hydrastine, and canadine, which are thought to contribute to its effects. Traditional herbal literature describes goldenseal as a "bitter tonic" that can stimulate digestion and help maintain the mucous membranes of the gut. However, modern scientific evidence supporting goldenseal's effectiveness for large intestine (colon) health is limited. While berberine (one of its key components) has demonstrated antimicrobial and antidiarrheal activity in laboratory and some clinical studies, most research has not specifically focused on goldenseal root or colon health outcomes. The traditional use is the primary justification for its inclusion in supplements aimed at colon support, but evidence from rigorous clinical trials is lacking. As such, the rating reflects a reliance on traditional and anecdotal use rather than strong scientific validation.

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