Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus paracasei is a probiotic strain that has been investigated for its potential to support individuals with lactose intolerance. The scientific rationale for its use centers on the strain’s ability to produce β-galactosidase (lactase), the enzyme responsible for breaking down lactose in the digestive tract. By increasing the availability of this enzyme in the gut, L. paracasei may help individuals with lactose intolerance better digest lactose-containing foods, thereby reducing symptoms such as bloating, gas, and diarrhea.

Several small-scale clinical studies and in vitro experiments have demonstrated that L. paracasei, either alone or as part of a multi-strain probiotic, can increase lactose digestion and improve symptoms in lactose-intolerant subjects. For example, studies have shown that fermented dairy products containing L. paracasei result in fewer symptoms compared to non-fermented dairy, likely due to the enzymatic activity of the bacteria. However, most clinical data are limited by small sample sizes, short durations, or the use of combination probiotic products, making it difficult to attribute benefits specifically to L. paracasei.

Overall, while there is a plausible scientific mechanism and some evidence supporting the use of L. paracasei for lactose intolerance, robust clinical evidence is still lacking. For this reason, the strength of evidence is moderate but not strong, and more well-designed, large-scale studies are needed to confirm efficacy.

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