Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus gasseri is a probiotic bacterium sometimes used as a supplement for digestive health, including the management of lactose intolerance. The rationale for its use stems from the ability of some probiotic strains to produce beta-galactosidase (lactase), the enzyme needed to digest lactose. Several in vitro studies have demonstrated that L. gasseri can express lactase activity, suggesting a possible mechanism by which it could alleviate symptoms of lactose intolerance by improving lactose digestion in the gut.

However, the clinical evidence in humans is limited. While some animal and laboratory studies suggest a potential benefit, there are few well-designed, placebo-controlled clinical trials directly evaluating the efficacy of L. gasseri for lactose intolerance. Reviews of probiotic interventions for lactose intolerance typically focus on other strains (such as Lactobacillus acidophilus, Lactobacillus bulgaricus, or Bifidobacterium species), which have stronger evidence bases. A handful of small studies, such as those cited in systematic reviews, mention L. gasseri as part of probiotic mixtures that may reduce symptoms, but the contribution of this specific strain is unclear.

In summary, there is a plausible scientific rationale, and some preliminary evidence, for the use of L. gasseri in lactose intolerance, but the quality and quantity of clinical data are low. Consequently, the overall strength of evidence is rated as 2 out of 5 for this indication.

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