Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Bovine-derived lactase (also known as β-galactosidase) is scientifically validated for the management of lactose intolerance. Lactose intolerance results from a deficiency in the enzyme lactase, which is necessary to digest lactose found in dairy products. Bovine lactase, extracted primarily from the small intestine of calves, is functionally similar to human lactase and is used in over-the-counter supplements to aid lactose digestion.

Clinical studies have demonstrated that supplemental lactase, including that derived from bovine sources, significantly reduces symptoms such as bloating, diarrhea, and abdominal pain in lactose-intolerant individuals. For example, a review published in the American Journal of Clinical Nutrition (1995) and subsequent meta-analyses have confirmed the efficacy of exogenous lactase in decreasing hydrogen production (a marker of malabsorption) and improving tolerance to lactose-containing foods. The FDA recognizes lactase enzyme supplements as generally recognized as safe (GRAS) for this purpose.

While microbial sources of lactase (e.g., from Aspergillus or Kluyveromyces species) are now more common due to ease of production and fewer allergenic concerns, bovine-derived lactase was historically one of the first enzyme therapies used for lactose intolerance. Its use is based on a clear understanding of the biochemical deficiency underlying the condition and direct evidence from clinical trials, making its application both logical and substantiated by modern science.

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