Nitrous oxide, commonly known as "laughing gas," is scientifically validated as a method for supporting labor and delivery, particularly for pain relief during childbirth. Its use in obstetric analgesia dates back to the late 19th and early 20th centuries, but contemporary research has reinforced its efficacy and safety profile. Nitrous oxide is typically administered as a 50:50 mix with oxygen, allowing laboring individuals to self-administer the inhaled agent as needed for pain relief.

Multiple clinical studies and systematic reviews have shown that nitrous oxide provides moderate analgesia during labor. While it is generally less effective than epidural anesthesia, nitrous oxide is valued for its rapid onset, quick clearance from the body, and minimal side effects for both mother and newborn. It does not impair uterine contractions or prolong labor, and its self-administered nature gives women a sense of control over their pain management.

The American College of Nurse-Midwives and several other national guidelines support its use as a safe and effective option for labor analgesia for those who prefer to avoid or are not candidates for more invasive procedures. Side effects are usually mild and may include nausea, dizziness, or drowsiness, but serious adverse events are rare.

In summary, nitrous oxide is a scientifically validated, low-risk option for labor pain relief, with a moderate level of efficacy and a long history of safe use in clinical practice.