Evidence supporting the use of: Glucosamine
For the health condition: Knees (weak)
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Glucosamine is commonly used as a dietary supplement to support knee health, particularly in people with osteoarthritis (OA). Its use is primarily justified by scientific research, though the strength of evidence is moderate and sometimes conflicting. Glucosamine is a natural compound found in cartilage, and the rationale for supplementation is that it may help support cartilage repair or slow its breakdown in degenerative joint conditions.
Several randomized controlled trials and meta-analyses have investigated glucosamine’s effects on knee osteoarthritis. Some studies have reported modest reductions in pain and improvements in function compared to placebo, especially with glucosamine sulfate (as opposed to glucosamine hydrochloride). However, other high-quality studies and systematic reviews have found limited or no clinically meaningful benefit. The 2019 guidelines from the American College of Rheumatology do not recommend glucosamine for OA due to inconsistent evidence, while some European guidelines are more favorable based on selected studies.
Overall, glucosamine is considered safe, with minimal side effects reported. It is widely used worldwide for knee joint health, largely because of its biological plausibility and the moderate but inconsistent evidence base. Its popularity is also driven by patient reports of perceived benefit and its traditional use in the management of joint complaints. Thus, while not universally endorsed by all guidelines, glucosamine remains a scientifically investigated option for people seeking to support knee health, particularly in the context of osteoarthritis.
Other health conditions supported by glucosamine
ArthritisCartilage Damage
Knees (weak)
Pets (supplements for)
