Evidence supporting the use of: Vitamin B6
For the health condition: Kidney Stones

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has been studied in relation to kidney stones, particularly those composed of calcium oxalate, the most common type. The rationale for its use stems from its role in oxalate metabolism. Vitamin B6 acts as a coenzyme for the conversion of glyoxylate to glycine, thereby reducing the formation of oxalate, which can contribute to stone formation. Early studies in the 1970s and 1980s suggested that vitamin B6 supplementation could lower urinary oxalate levels and potentially reduce the risk of kidney stone recurrence, especially in individuals with primary hyperoxaluria or idiopathic hyperoxaluria.

However, subsequent research has produced mixed results. While some small studies and case reports found a benefit, larger and more recent clinical trials and reviews have failed to consistently demonstrate a significant reduction in stone recurrence with vitamin B6 supplementation in the general population. The American Urological Association and other major guidelines do not currently recommend vitamin B6 supplementation as a standard preventive therapy for kidney stones, except in rare cases of vitamin B6 deficiency or specific metabolic disorders.

In summary, while there is a plausible biochemical mechanism and some early scientific studies supporting its use, the overall quality and consistency of evidence is low. Therefore, vitamin B6 is not considered a primary or universally recommended therapy for kidney stone prevention, though it may have a role in select populations.

More about vitamin B6
More about Kidney Stones

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