Plectranthus amboinicus, commonly known as Indian borage or Cuban oregano, has a long history of use in traditional medicine systems, particularly in South Asia and parts of Africa. Traditionally, it has been employed for a variety of ailments, including respiratory issues, digestive disturbances, and urinary problems. Its application for kidney-related conditions, including kidney infections, is documented in ethnobotanical literature, where leaves are used as infusions or decoctions. However, these uses are based on cultural practices and anecdotal reports rather than rigorous scientific validation.

The scientific literature offers limited direct evidence supporting the effectiveness of Plectranthus amboinicus in treating or supporting kidney infections (pyelonephritis). Some studies have identified the plant's antimicrobial and anti-inflammatory properties, which are relevant to infections in general, but no clinical trials or robust preclinical studies specifically address kidney infections. In summary, its use for kidney infection is rooted primarily in tradition, with very weak or indirect scientific support, and should not be considered a substitute for evidence-based medical treatment.