Pentatropis capensis, a plant belonging to the family Asclepiadaceae, is primarily cited in traditional medicine systems for its various medicinal uses, including the treatment of kidney infections and other urinary tract issues. Ethnobotanical surveys in regions such as India and Africa have documented its use by local healers for addressing ailments related to the kidneys, likely due to perceived diuretic, anti-inflammatory, or antimicrobial properties. However, scientific validation for these uses is extremely limited. There is a lack of peer-reviewed pharmacological studies directly assessing the efficacy, active constituents, or mechanisms of action of Pentatropis capensis in treating kidney infections. The evidence supporting its use is thus largely anecdotal and based on traditional reports rather than scientific data. Without controlled studies or clinical trials, the safety and effectiveness of Pentatropis capensis for kidney infections remain unproven. Therefore, its application for kidney infections should be considered speculative and approached with caution, particularly given the seriousness of such infections and the risks of forgoing evidence-based medical treatment.